New antiviral antibiotics; xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether. I. Isolation and characterization. (Studies on antiviral and antitumor antibiotics. V).

New antiviral antibiotics; xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether. II. Biological aspects of antiviral activity. (Studies on antiviral and antitumor antibiotics. VI).

Effects of XME, XDE and XTE (xanthocillin X monoand dimethylether, and methoxy-xanthocillin X dimethylether) on multiplication of Newcastle disease virus (NDV) and on proliferation of chick embryo fibroblast cells (CEF) were examined. At low multiplicity, XME, XDE and XTE suppressed CPE at low concentrations. At high multiplicity, XME (10 mcg/ml) completely inhibited occurrence of CPE and synth...

Xanthocillin X monomethyl ether, a potent inhibitor of prostaglandin biosynthesis.

Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of Dichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 microM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 microM. The inhibition of xanthoc...

Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I).

A new antibiotic, ascochlorin, C23H29O4CI, was obtained from the filter cake of the fermented broth of Ascochyta viciae Libert. Ascochlorin inhibits plaque formation of both DNA and RNA viruses in the agar-diffusion plaque inhibition method. However, it showed no antiviral activity by the tube culture method. It showed cytotoxicity to chick embryo fibroblast monolayer and HeLa cells at a concen...

SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway

A compound named SD118-xanthocillin X (1) (C(18)H(12)N(2)O(2)), isolated from Penicillium commune in a deep-sea sediment sample, has been shown to inhibit the growth of several cancer cell lines in vitro. In the present study, we employed a growth inhibition assay and apoptotic analysis to identify the biological effect and detailed mechanism of SD118-xanthocillin X (1) in human hepatocellular ...

Antiviral activity of mycophenolic acid. Studies on antiviral and antitumor antibiotics. IV.